For queries about the service please contact the Queen Elizabeth University Hospital Biochemistry Department on 0141 354 9060.
About the service
The Scottish Biologic Drug Monitoring Service is delivered by the Biochemistry Dept. within the Lab Medicine Building on the Queen Elizabeth University Hospital site, Glasgow.
The service currently delivers Infliximab and Adalimumab levels and their respective total anti-drug antibodies (ADA) for optimising care predominantly in gastroenterology patients with inflammatory bowel disease. The service attained UKAS accreditation (2019) and is working with IMMQAS and others to improve the EQA understanding for drug and ADA assays. The service uses both WHO standards for drug levels and a patient pool sample for ADA assay to monitor performance. It is involved in sample exchange with other laboratories.
The service employs a reflex ADA testing strategy based on drug level result. When a drug level result is within or higher than the therapeutic target range, and when ADA level has previously been undetectable, reflex ADA testing is not routinely performed. Since the introduction of reflex ADA testing approximately 50% adalimumab samples and 37% infliximab samples have not had a reflex ADA test performed.
There may be some clinical scenarios where ADA titres are desirable even when drug level results are therapeutic. Requests for additional ADA testing should be indicated clearly at the time of test request or can be arranged by contacting the lab directly.
During 2019 there were 2821 Infliximab and 2920 Adalimumab samples analysed from health boards across Scotland.
TDM tests should be requested according to local biochemistry/immunology laboratory requirements. The previously used paper request forms are no longer required. Local teams are encouraged to collate data related to TDM use and outcomes as this may be required to sustain future rounds of service funding.
Specific Rheumatology guidance
Specific Gastroenterology guidance
Vedolizumab drug level and antibody testing
Vedolizumab drug level testing is now available. The utility of testing drug and anti-drug antibodies for vedolizumab has yet to be fully ascertained. Target drug levels for vedolizumab have not been clearly established. The current evidence is covered in these articles:
Vedolizumab testing is not part of the nationally commissioned TDM service. The cost per sample is £20.
In order to gather clinical data regarding the benefits of vedolizumab drug level testing, please complete and enclose a completed request form with each sample. This information will be used to try and secure UKAS accreditation for vedolizumab drug level testing. Vedolizumab Request Audit Form.
Clyde Biochemistry Laboratories (those based at Royal Alexandra Hospital, Inverclyde Royal Hospital and Vale of Leven Hospital) has been accredited with UKAS to standard ISO 15189:2012 for much of our test repertoire. The certificate of accreditation is available online.
The scope of our accreditation includes the majority of the tests performed by our laboratories, with a small number of tests not falling within our accreditation status (for example, no fluid analyses (on fluids other than CSF, urine or blood / serum / plasma) are accredited) – see the link above for details of our accredited scope.
Specialist services including Protein Electrophoresis and less often requested endocrine assays are based at RAH.
All routine GP work within the Clyde Sector is also based at RAH.
Please accept our apologies for the behaviour of links on this webpage. This is due to a global setting which is outwith the Biochemistry Department’s control.
Service Hours
Routine operating hours
- Monday to Friday, 8.30am to 5.00pm
- Saturday and Sunday, 8.30am to 12.00pm (Inverclyde Royal Hospital) and 9.00am to 12.00pm (Royal Alexandra Hospital)
- There is a 24hr emergency service for urgent samples outwith these hours
Contact Details
Royal Alexandra Hospital (RAH)
- Address: Corsebar Road, Paisley, Renfrewshire PA2 9PN
- Telephone: 0141 314 6157 extention 06157
Inverclyde Royal Hospital (IRH)
- Address: Larkfield Road, Greenock PA16 0XN
- Telephone: 01475 504827 extention 04827 – Emergency requests extention 04213
Vale of Leven Hospital (VOL)
- Main Street, Alexandria G83 0UA
- Telephone: 01389 817568 extention 87568
POCT issues / Cryoglobulin testing
For routine issues with gas analysers or blood glucose meters and to arrange training / barcode for meters please email:
Cryoglobulin testing can also be arranged via this email address.
Clinical Advice
Both Primary and Secondary care professionals served by the Clyde Biochemistry Laboratory can obtain clinical advice by email:
Feedback
We are committed to providing a quality service to users. If you wish to provide feedback on the Clyde Glasgow Biochemistry service, please contact our Quality Manager by emailing Pamela.craig@ggc.scot.nhs.uk.
Handbooks and Manuals
Laboratory Newsletter
The most recent laboratory newsletter is available below:
Previous issues of the newsletter are stored in the Clyde Biochemistry Document Library:
Memos
Primary Care
Secondary Care
Previous memos can be found in the Clyde Biochemistry Document Library, linked above.
This page is currently under review and will be updated imminently to reflect the HFEAs most recent data.