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Orthopaedic Research

The Orthopaedic Research Department is the main site for a number of clinical trials and we work alongside the Glasgow Clinical Research Facility (GCRF) to manage patient data for these trials. Additionally, we collaborate closely with the University of Strathclyde and the Gait Lab located in the GCRF to understand the biomechanics of gait following knee replacements. Click on the links below for more information on the on-going trials.

Patient and Public Involvement & Engagement

The Orthopaedic Research Department will be recruiting patient representatives to help us shape our research portfolio. Please check back here in future for more information. Please contact Dr James Doonan at iii-ortho-research@glasgow.ac.uk if you would like more information on the research activities currently on-going in the Department, to discuss participating in an on-going clinical trial or to be considered as a patient representative.

TRUCK

Study Title: Explanatory comparative study of conventional Total Knee Arthroplasty versus Robotic assisted Bi-UniCompartmental Knee Arthroplasty

Trial Participants: Patients with osteoarthritis of the knee affecting both the inside and outside compartments of the joint that require total knee replacement surgery.

Recruitment: Closed

Overview: This randomised controlled trial will compare the novel robotic assisted Bi-Unicompartmental knee replacement surgical techniques which replaces the only damaged components of the knee joint against the standard total knee replacement surgical technique. The rationale for this study is that patients will have a more natural feeling knee joint by only removing the damaged bone tissue and preserving the joint space as appose to using the standard surgical implant. 

Objectives:

  1. To provide evidence of the efficacy and safety of using robotic assisted Bi-Unicompartmental knee replacements.
  2. To determine the biomechanical benefit of using robotic assisted Bi-Unicompartmental knee replacements to patients gait, surgical and functional outcomes and patient satisfaction.
iNAV

Study Title: To compare the results of total knee surgery using conventional instrumentation versus the iNav electromagnetic computer navigated system

Trial Participants: Patients with osteoarthritis of the knee that require total knee replacement surgery.

Recruitment: Closed

Overview: This randomised controlled trial will compare the standard total knee replacement surgery with a new surgical assisted iNav system. The rationale for this study is that by using computer navigated surgical assistance there will be reduced variation between surgeries and improved placement of implants which might improve patient outcomes and satisfaction.  

Objectives:

  1. The alignment and knee implant placement will be verified and compared in conventional and iNav surgical groups
  2. The influence of both treatments on the surgical and functional outcomes, and patient satisfaction will be evaluated
KINESPRING

Study Title: Clinical Evaluation of the MOXIMED KineSpring® Knee Implant System

Trial Participants: Patients with osteoarthritis of the knee who would require unicompartmental knee replacement or high tibial osteotomy.

Recruitment: Closed

Overview: This study is aimed at evaluating the long term safety and clinical efficacy of the MOXIMED KineSpring® knee implant. All patients recruited to this study received a Kinespring implant and are being followed up for up to 10 years.

Objectives:

  1. The functional and clinical outcome scores of all patients 1 year after surgery
  2. A number of additional outcomes will be monitored over a 10 year period including patient satisfaction, pain levels, and functional outcomes.
MAKO

Study Title: MAKOplasty unicondylar knee arthroplasty using MAKOplasty® and the MAKO RIO System versus OXFORD Partial Knee Arthroplasty

Trial Participants: Patients with osteoarthritis who require a unicondylar knee replacement

Recruitment: Closed

Overview: This randomised controlled trial will compare standard OXFORD Unicompartmental knee arthroplasty with the novel MAKO unicondylar knee arthroplasty which requires the robotic arm surgical assistance. The rationale for this study is that the robotic assisted surgery will target only diseased bone tissue for removal. This provides increased accuracy for implant fixation in addition to the use unicondylar knee arthroplasty compared to standard treatment which might improve patient outcomes as less of the joint is removed.

Objectives:

  1. To compare the alignment of implants and knee joints in both groups of patients.
  2. The clinical and functional outcomes of both patients will be compared between both treatment groups.
SUN Study

Study Title: Negative pressure dressing versus non-negative pressure dressing for soft tissue sarcoma excision

Trial Participants: Patients diagnosed with soft tissue sarcoma that are scheduled for surgical removal.

Recruitment: We are aiming to recruit 160 patients in Glasgow Royal Infirmary.  

Overview: This randomised controlled clinical trial will compare two types of wound dressing which are applied to the wound after closure with stitches. Either standard wound dressings are applied, or negative pressure wound dressings are applied for the duration of your recovery in hospital. Both treatments are used clinically but have not been directly compared in patients undergoing cancer removal operations.

Objectives:

  1. The incidence of surgical site infections will be compared between the two groups
  2. The time for wound healing and surgical drain volumes will be recorded and compared between both treatment groups
  3. The functional assessment of each wound will be clinical assessed and compared between treatment groups.